ANGIOTENSIN-II EXERTS ITS EFFECT ON ALDOSTERONE PRODUCTION AND POTASSIUM PERMEABILITY THROUGH RECEPTOR SUBTYPE-AT1 IN RAT ADRENAL GLOMERULOSA CELLS

被引：26

作者：

HAJNOCZKY, G

CSORDAS, G

BAGO, A

CHIU, AT

SPAT, A

机构：

[1] SEMMELWEIS UNIV,SCH MED,DEPT PHYSIOL,POB 259,H-1444 BUDAPEST 8,HUNGARY

[2] DUPONT CO,DEPT MED PROD,WILMINGTON,DE 19800

来源：

BIOCHEMICAL PHARMACOLOGY | 1992年 / 43卷 / 05期

基金：

匈牙利科学研究基金会;

关键词：

D O I：

10.1016/0006-2952(92)90606-J

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The stimulatory effect of angiotensin II (AT) on the accumulation of inositol phosphates and on aldosterone production is abolished by the AT1 selective receptor antagonist DuP753 while PD123177, an AT2 antagonist, is ineffective. Similarly, a depolarizing effect of AT (inhibition of K+/Rb-86 efflux) is prevented by DuP753. While mediators derived from phospholipase C activation have a central role in the stimulation of aldosterone production by AT, the effect of AT on K+ permeability is mimicked neither by elevation of cytoplasmic [Ca2+] by ionomycin nor by kinase C activation with phorbol ester. Our results suggest that AT stimulates phospholipase C and the subsequent steroid production by glomerulosa cells through AT1 receptors. In addition some events induced by the activation of AT1 receptors may not be mediated by the activation of phospholipase C.

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页码：1009 / 1012

页数：4

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