CYTOLYTIC LYMPHOCYTES-T SPECIFIC FOR TUMORS AND INFECTED-CELLS FROM MICE WITH A RETROVIRUS-INDUCED IMMUNODEFICIENCY SYNDROME

被引：10

作者：

ERBE, JG

GREEN, KA

CRASSI, KM

MORSE, HC

GREEN, WR

机构：

[1] DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,DEPT MICROBIOL,HANOVER,NH 03756

[2] DARTMOUTH COLL,HITCHCOCK MED CTR,DARTMOUTH MED SCH,NORRIS COTTON CANC CTR,HANOVER,NH 03756

[3] NIAID,IMMUNOPATHOL LAB,BETHESDA,MD 20892

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 05期

关键词：

D O I：

10.1128/JVI.66.5.3251-3256.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

LP-BM5 retrovirus complex-infected C57BL/6 mice develop immunodeficiency, somewhat analogous to AIDS, termed murine AIDS (MAIDS). After secondary stimulation with syngeneic B-cell lymphomas from LP-BM5-infected mice, C57BL/6 mice produced vigorous CD8+ cytotoxic T lymphocytes specific for MAIDS-associated tumors. An anti-LP-BM5 specificity was suggested because spleen and lymph node cells from LP-BM5-infected mice served as target cells in competition assays, and cells from LP-BM5, but not ecotropic, virus-infected mice functioned as secondary in vitro stimulators to generate cytotoxic T lymphocytes to MAIDS tumors.

引用

收藏

页码：3251 / 3256

页数：6

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