SYNTHESIS OF CHIRAL ZILEUTON, A POTENT AND SELECTIVE INHIBITOR OF 5-LIPOXYGENASE

被引：52

作者：

HSIAO, CN

KOLASA, T

机构：

[1] Abbott Laboratories, Department 45L / AP 10, Process Chemistry

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(00)79043-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Coupling and intramolecular Wittig reaction of N-benzyloxy-D-alanine anhydride (13) and (2-Mercaptophenyl)methyltriphenylphosphonium bromide (3) were used as key steps to prepare (+)-enantiomer of zileuton (1), a potent and selective inhibitor of 5-lipoxygenase.

引用

页码：2629 / 2632

页数：4

共 13 条

[1]

AKIYAMA M, 1979, TETRAHEDRON LETT, V19, P2599

[2]

ARNOLDI A, 1988, SYNTHESIS-STUTTGART, P155

[3] ADDITION OF ORGANOLITHIUM COMPOUNDS TO N-THP PROTECTED NITRONE [J].