CHROMOSOME PAINTING IN ACUTE MONOCYTIC LEUKEMIA

被引：24

作者：

CHERIF, D

ROMANA, S

DERSARKISSIAN, H

JONES, C

BERGER, R

机构：

[1] INST GENET MOLEC,INSERM,U301,27 RUE JULIETTE DODU,F-75010 PARIS,FRANCE

[2] INST GENET MOLEC,CTR ETUD POLYMORPHISME HUMAIN,PARIS,FRANCE

[3] ELEANOR ROOSEVELT INST,DENVER,CO

来源：

GENES CHROMOSOMES & CANCER | 1993年 / 6卷 / 02期

关键词：

D O I：

10.1002/gcc.2870060207

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An Alu polymerase chain reaction (PCR) probe specific for chromosome 11 prepared from the somatic cell hybrid JI was used to analyze karyotypes of eight patients with acute monocytic leukemia (AML-M5). Chromosome painting confirmed the t(9;11) in one patient and a der(1)t(1;6)t(6;11) in another and allowed the identification of a complex rearrangement involving chromosomes 9, 11, and 17, previously classified as del(11)(q23), in a third patient. An analysis of five patients with AML-MS and a normal karyotype did not detect abnormalities of chromosome 11. The usefulness of chromosome painting combined with in situ hybridization with probes previously located on particular chromosomes is emphasized.

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收藏

页码：107 / 112

页数：6

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