NMDA (NMDAR1) AND AMPA-TYPE (GLUR2/3) RECEPTOR SUBUNITS ARE EXPRESSED IN THE INNER-EAR

被引：55

作者：

USAMI, S ^{[1
]}

MATSUBARA, A ^{[1
]}

FUJITA, S ^{[1
]}

SHINKAWA, H ^{[1
]}

HAYASHI, M ^{[1
]}

机构：

[1] PRIMATE RES INST, KYOTO, JAPAN

来源：

NEUROREPORT | 1995年 / 6卷 / 08期

关键词：

GLUTAMATE RECEPTOR; NMDA; AMPA; RAT; GUINEA PIG; MONKEY; INNER EAR; IMMUNOCYTOCHEMISTRY;

D O I：

10.1097/00001756-199505300-00022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

USING receptor subunit-specific antibodies, the cellular localization of NMDA and AMPA type glutamate receptor subunits was studied within the rodent (rat, guinea pig) and non-human primate (monkey) inner ear. In the spiral and vestibular ganglion, almost all cells were immunoreactive for the NMDAR1 subunit and the AMPA type receptor subunit GluR2/3. This indicates that both NMDA and non-NMDA type glutamate receptors may be co-distributed in the primary afferent neuronal components, and are possibly involved in neurotransmission in the primary auditory and vestibular systems. This study also indicated the possible localizations of glutamate receptors in the nonneuronal cells in the inner ear, suggesting that some nonneuronal cells may also have the ability to mediate glutamate signalling.

引用

页码：1161 / 1164

页数：4

共 20 条

[1] NMDA AND NON-NMDA RECEPTORS ARE CO-LOCALIZED AT INDIVIDUAL EXCITATORY SYNAPSES IN CULTURED RAT HIPPOCAMPUS [J].