PREVALENCE OF THE FRAGILE-X SYNDROME IN AN INSTITUTION FOR THE MENTALLY-HANDICAPPED

被引：25

作者：

PRIMROSE, DA

ELMATMATI, R

BOYD, E

GOSDEN, C

NEWTON, M

机构：

[1] DUNCAN GUTHRIE INST MED GENET, GLASGOW, SCOTLAND

[2] ROYAL SCOTTISH NATL HOSP, LARBERT FK5 4EJ, STIRLING, SCOTLAND

[3] MRC, CLIN & POPULAT CYTOGENET UNIT, EDINBURGH, SCOTLAND

[4] UNIV LONDON KINGS COLL HOSP, HUMAN GENET, LONDON SE5 9RS, ENGLAND

来源：

BRITISH JOURNAL OF PSYCHIATRY | 1986年 / 148卷

关键词：

D O I：

10.1192/bjp.148.6.655

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

In an investigation to find the prevalence of the fragile X (Martin Bell) syndrome in a mental handicap hospital, chromosomal investigations were carried out in 196 males selected out of a total of 512, and also in 20 female patients who were related to some of the selected males. Fragile X cells were found in 41 of the males and two of the females; in 21 of the males it was associated with macro-orchidism. The overall prevalence in the hospital for males (8.0%) ranks this syndrome next in importance to Down''s syndrome as a known cause for mental handicap.

引用

页码：655 / 657

页数：3

共 11 条

[1] BLOMQUIST HK, 1982, CLIN GENET, V21, P209
[2] THE DIAGNOSIS AND FREQUENCY OF X-LINKED CONDITIONS IN A COHORT OF MODERATELY RETARDED MALES WITH AFFECTED BROTHERS
FISHBURN, J
TURNER, G
DANIEL, A
BROOKWELL, R
[J]. AMERICAN JOURNAL OF MEDICAL GENETICS, 1983, 14 (04): : 713 - 724
[3] SCREENING FOR FRA(X)(Q) IN A POPULATION OF MENTALLY-RETARDED MALES
FROSTERISKENIUS, U
FELSCH, G
SCHIRREN, C
SCHWINGER, E
[J]. HUMAN GENETICS, 1983, 63 (02) : 153 - 157
[4] SCREENING OF MENTALLY-RETARDED MALES FOR MACRO-ORCHIDISM AND THE FRAGILE-X CHROMOSOME
HOWARDPEEBLES, PN
FINLEY, WH
[J]. AMERICAN JOURNAL OF MEDICAL GENETICS, 1983, 15 (04): : 631 - 635
[5] A CYTOGENETIC STUDY OF A POPULATION OF MENTALLY-RETARDED MALES WITH SPECIAL REFERENCE TO THE MARKER(X) SYNDROME
JACOBS, PA
MAYER, M
MATSUURA, J
RHOADS, F
YEE, SC
[J]. HUMAN GENETICS, 1983, 63 (02) : 139 - 148
[6] A pedigree of mental defect showing sex-linkage
Martin, JP
Bell, J
[J]. JOURNAL OF NEUROLOGY AND PSYCHIATRY, 1943, 6 (3/4): : 154 - 157
[7] MACRO-ORCHIDISM AND FRAGILE-X IN MENTALLY-RETARDED MALES - CLINICAL, CYTOGENETIC, AND SOME HORMONAL INVESTIGATIONS IN MENTALLY-RETARDED MALES, INCLUDING 2 WITH THE FRAGILE SITE AT XQ28, FRA(X)(Q28)
NIELSEN, KB
TOMMERUP, N
DYGGVE, HV
SCHOU, C
[J]. HUMAN GENETICS, 1982, 61 (02) : 113 - 117
[8] CONFERENCE REPORT - INTERNATIONAL WORKSHOP ON THE FRAGILE-X AND X-LINKED MENTAL-RETARDATION
OPITZ, JM
SUTHERLAND, GR
[J]. AMERICAN JOURNAL OF MEDICAL GENETICS, 1984, 17 (01): : 5 - 94
[9] THE MARTIN-BELL-RENPENNING SYNDROME
RICHARDS, BW
WEBB, T
[J]. JOURNAL OF MEDICAL GENETICS, 1982, 19 (01) : 79 - 79
[10] SUTHERLAND GR, 1982, AM J HUM GENET, V34, P452

← 1 2 →