THIOUREA REVERSES CROSS-LINKS AND RESTORES BIOLOGICAL-ACTIVITY IN DNA TREATED WITH DICHLORODIAMINOPLATINUM(II)

被引：101

作者：

FILIPSKI, J

KOHN, KW

PRATHER, R

BONNER, WM

机构：

[1] Laboratory of Molecular Pharmacology, Division of Cancer Treatment, National Cancer Institute, Bethesda

来源：

SCIENCE | 1979年 / 204卷 / 4389期

关键词：

D O I：

10.1126/science.571145

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cis and trans dichlorodiaminoplatinum(II) compounds bind to DNA and form DNA cross-links, which are usually considered to be irreversible. Thiourea can reverse these cross-links without any apparent breakdown of the DNA. In addition, cis- and trans-Pt(II) treatment of λ DNA decreases its transfectivity. After suitable incubation with thiourea, full transfectivity of Pt(II)-treated λ DNA can be restored. Copyright © 1979 AAAS.

引用

页码：181 / 183

页数：3

共 14 条

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