EORTC PHASE-II STUDY OF CISPLATIN IN CYVADIC-RESISTANT SOFT-TISSUE SARCOMA

被引：27

作者：

BRAMWELL, VHC

BRUGAROLAS, A

MOURIDSEN, HT

CHEIX, F

DEJAGER, R

VANOOSTEROM, AT

VENDRIK, CP

PINEDO, HM

SYLVESTER, R

DEPAUW, M

机构：

[1] FREE UNIV AMSTERDAM,ACAD ZIEKENHUIS,AMSTERDAM,NETHERLANDS

[2] INST JULES BORDET,SERV MED INTERNE,EORTC DATA CTR,B-1000 BRUSSELS,BELGIUM

[3] FINSEN INST,DEPT R11,DK-2100 COPENHAGEN,DENMARK

[4] ACAD ZIEKENHUIS LEIDEN,DEPT RADIOTHERAPY & MED ONCOL,LEIDEN,NETHERLANDS

[5] CTR LEON BERARD,F-69373 LYON 2,FRANCE

[6] HOSP GEN ASTURIAS,CTR ONCOL POLICLIN,OVIEDO,SPAIN

[7] ACAD ZIEKENHUIS UTRECHT,UTRECHT,NETHERLANDS

来源：

EUROPEAN JOURNAL OF CANCER | 1979年 / 15卷 / 12期

关键词：

D O I：

10.1016/0014-2964(79)90032-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cis-diamminodichloroplatinum (II) (cis-DDP), 100 mg/m2 every 3 weeks was administered to 24 patients with advanced soft tissue sarcoma. All patients had received extensive prior chemotherapy and had measurable progressive disease and normal renal function on entry to the study. There were no objective responses in the 17 patients receiving an adequate trial of therapy. Nausea and vomiting were universal. Renal impairment was moderate in 2 patients and mild in 4. Serial audiometry detected hearing loss at high frequencies in 3 patients. © 1979.

引用

页码：1511 / 1513

页数：3

共 17 条

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[7] 2-J
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