SYNTHESIS OF 1H-IMIDAZO[4,5-C]QUINOLIN-4(5H)-ONE VIA PALLADIUM-CATALYZED CYCLIZATION OF N-(2-BROMOPHENYL)-1H-IMIDAZOLE-4-CARBOXAMIDE

被引：47

作者：

KURODA, T ^{[1
]}

SUZUKI, F ^{[1
]}

机构：

[1] KYOWA HAKKO KOGYO CO LTD,PHARMACEUT RES LABS,1188 SHIMOTOGARI,NAGAIZUM CHO,SHIZUOKA 411,JAPAN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 47期

关键词：

D O I：

10.1016/0040-4039(91)80443-A

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new heterocycle, 5-butyl-1-methyl-1H-imidazo[4,5-c]quinolin-4(5H)-one has been synthesized using palladium-catalyzed cyclization. A yield of the cyclization was optimized by changing base, additive and reaction temperature.

引用

页码：6915 / 6918

页数：4

共 6 条

[1] PALLADIUM-CATALYZED CYCLIZATION OF 2-SUBSTITUTED HALOGENOARENES BY DEHYDROHALOGENATION [J].

AMES, DE ;

OPALKO, A .

TETRAHEDRON, 1984, 40 (10) :1919-1925

[2] SOME REACTIONS OF 3-HALOGENOCINNOLINES CATALYZED BY PALLADIUM COMPOUNDS [J].

AMES, DE ;

BULL, D .

TETRAHEDRON, 1982, 38 (03) :383-387

[3] PALLADIUM-CATALYZED VINYLATION OF ORGANIC HALIDES UNDER SOLID LIQUID-PHASE TRANSFER CONDITIONS [J].

JEFFERY, T .

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1984, (19) :1287-1289

[4]

KASINA S, 1975, SYNTHESIS-STUTTGART, P162

[5] REACTIONS OF IMIDAZOLES WITH ISOCYANATES AT ELEVATED-TEMPERATURE [J].

PAPADOPOULOS, EP .

JOURNAL OF ORGANIC CHEMISTRY, 1977, 42 (24) :3925-3929

[6]

SUZUKI F, 1991, Patent No. 4994468

← 1 →