EPIDURAL BUPIVACAINE, SUFENTANIL OR THE COMBINATION FOR POSTTHORACOTOMY PAIN

被引:53
作者
MOURISSE, J
HASENBOS, MAWM
GIELEN, MJM
MOLL, JE
CROMHEECKE, GJE
机构
[1] Institute for Anaesthesiology, University of Nijmegen, Nijmegen
关键词
ANESTHETIC TECHNIQUES; REGIONAL; EPIDURAL; LOCAL ANESTHETIC; BUPIVACAINE; OPIOID; SUFENTANIL;
D O I
10.1111/j.1399-6576.1992.tb03425.x
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Analgesia with epidural bupivacaine, sufentanil or the combination was studied in 50 patients who had undergone thoracotomy. During operation all patients received an initial dose of bupivacaine 0.5% with adrenaline 5-mu-g.ml-1 (5-10 ml) by thoracic epidural catheter. One hour later the patients were divided into three groups: the bupivacaine group (bupivacaine 0.125%), the sufentanil group (50-mu-g sufentanil in 60 ml normal saline) and the combination group (50-mu-g sufentanil in 60 ml bupivacaine 0.125%). Analgesia in the three groups was provided by a continuous epidural infusion (5-10 ml.h-1) for 3 days. The mean dose of bupivacaine was significantly higher (P < 0.05) in the bupivacaine group (12.07 mg.h-1 (s.e. mean 0.97 mg.h-1)), compared with the combination group (9.82 mg.h-1 (s.e. mean 0.43 mg.h-1)). The mean dose of sufentanil in the sufentanil group was similar to the combination group (6.37-mu-g.h-1 (s.e. mean 0.23-mu-g.h-1) and 6.52-mu-g.h-1 (s.e. mean 0.28-mu-g.h-1), respectively. The pain scores on the inverse visual analogue scale of most patients in the bupivacaine group were unacceptably low. The sufentanil group had much better pain scores, but on exercise these patients experienced more pain than the combination group. The combination group had, overall, better pain scores. In the combination group, there were better respiratory results.
引用
收藏
页码:70 / 74
页数:5
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