SINGLE-DOSE PHARMACOKINETICS OF RECOMBINANT-HUMAN-ERYTHROPOIETIN IN PRETERM INFANTS AFTER INTRAVENOUS AND SUBCUTANEOUS ADMINISTRATION

被引：41

作者：

BROWN, MS

JONES, MA

OHLS, RK

CHRISTENSEN, RD

机构：

[1] SWEDISH MED CTR, DEPT PHARMACOL, DENVER, CO USA

[2] UNIV UTAH, SCH MED, DIV HUMAN DEV & AGING, SALT LAKE CITY, UT 84112 USA

来源：

JOURNAL OF PEDIATRICS | 1993年 / 122卷 / 04期

关键词：

D O I：

10.1016/S0022-3476(05)83559-0

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Pharmacokinetics of recombinant human erythropoietin (rHuEPO) were studied in a group of very low birth weight infants after both intravenous and subcutaneous administration. The volume of distribution was larger and the clearance more rapid than those reported in adults. The maximum concentration of erythropoietin after subcutaneous doses of rHuEPO was variable, but bioavailability was high (42%) compared with values reported in adults. These observations could be useful in optimizing treatment of the anemia of prematurity with rHuEPO.

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页码：655 / 657

页数：3

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