CLONING AND CHARACTERIZATION OF A CDNA-ENCODING RAT PKR, THE DOUBLE-STRANDED RNA-DEPENDENT EUKARYOTIC INITIATION FACTOR-II KINASE

被引：25

作者：

MELLOR, H ^{[1
]}

FLOWERS, KM ^{[1
]}

KIMBALL, SR ^{[1
]}

JEFFERSON, LS ^{[1
]}

机构：

[1] PENN STATE UNIV,COLL MED,DEPT CELLULAR & MOLEC PHYSIOL,HERSHEY,PA 17033

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1994年 / 1219卷 / 03期

关键词：

PROTEIN SYNTHESIS; PROTEIN KINASE; RNA-BINDING PROTEIN; CDNA; (RAT);

D O I：

10.1016/0167-4781(94)90229-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated and sequenced a full-length cDNA encoding the double-stranded RNA-dependent protein kinase PKR from rat. The derived amino acid sequences of the protein kinase and RNA-binding domains are highly conserved between the rat, human and mouse enzymes. In addition, sequence elements in the 5'- and 3'-untranslated regions are also conserved between species.

引用

页码：693 / 696

页数：4

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