CORRELATION OF OCTANOL WATER SOLUBILITY RATIOS AND PARTITION-COEFFICIENTS

被引：64

作者：

PINSUWAN, S ^{[1
]}

LI, A ^{[1
]}

YALKOWSKY, SH ^{[1
]}

机构：

[1] UNIV ARIZONA, DEPT PHARMACEUT SCI, TUCSON, AZ 85721 USA

来源：

JOURNAL OF CHEMICAL AND ENGINEERING DATA | 1995年 / 40卷 / 03期

关键词：

D O I：

10.1021/je00019a019

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

The octanol/water solubility ratio (S-O/S-W) was found to be highly correlated with the octanol/water partition coefficient (K-OW) of 82 pharmaceutically and environmentally relevant compounds. The solubility ratio gives comparable estimates to that of the group contribution (log P(calcd)) method for estimating the partition coefficient of the compounds used in this study.

引用

页码：623 / 626

页数：4

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