LOW MOLECULAR WEIGHT METHYLATED RIBONUCLEIC ACID SPECIES FROM CHINESE HAMSTER OVARY CELLS .I. ISOLATION AND CHARACTERIZATION

Preparative polyacrylamide gel electrophoresis has been used to isolate four methylated, low molecular weight ribonucleic acid molecules from Chinese hamster cells. They have been shown to be distinct from transfer ribonucleic acid and 5S ribosomal ribonucleic acid and are found in a fraction enriched with respect to nuclei. Investigation of the products of alkaline hydrolysis of three of these supports the conclusion that they are unique ribonucleic acid species, distinguishable from other known methylated ribonucleic acids or from their possible breakdown products. © 1969, American Chemical Society. All rights reserved.