CONFORMATIONS OF TRIOSTIN-A IN SOLUTION

被引：30

作者：

KALMAN, JR

BLAKE, TJ

WILLIAMS, DH

FEENEY, J

ROBERTS, GCK

机构：

[1] UNIV CAMBRIDGE, CHEM LAB, CAMBRIDGE CB2 1EW, ENGLAND

[2] NATL INST MED RES, LONDON NW7 1AA, ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1979年 / 05期

关键词：

D O I：

10.1039/p19790001313

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The two symmetrical conformations of triostin A in deuteriochloroform have been investigated by 1H n.m.r. spectroscopy. The occurrence of two conformations is rationalised as resulting from the reversal of chirality of the disulphide bond, which is postulated to exist as a rapidly interconverting mixture of several rotameric states. Analysis of the spectrum of the least polar conformer is consistent with the presence of an intramolecular hydrogen bond.

引用

页码：1313 / 1321

页数：9

共 27 条

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