OCCURRENCE OF INV GENETIC MARKERS IN SUBGROUPS OF HUMAN KAPPA CHAINS

被引：15

作者：

MILSTEIN, C

JARVIS, JM

MILSTEIN, CP

机构：

[1] Medical Research Council Laboratory of Molecular Biology Cambridge, England

[2] Agricultural Research Council Institute of Animal Physiology Babraham, Cambridge, England

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1969年 / 46卷 / 03期

关键词：

D O I：

10.1016/0022-2836(69)90202-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two immunoglobulin kappa chains were selected out of several carrying the genetic marker Inv (1,2) and shown to be very similar to other kappa chains of the subgroup κII. The three subgroups (κI, κII and κIII) of the amino terminal halves (variable region) are thus shown to be associated with either leucine or valine at residue 191 in the carboxyterminal half (constant region). The results provide additional evidence for the requirement of an integration mechanism during the control of immunoglobulin synthesis. © 1969.

引用

页码：599 / +

页数：1

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