DIFFERENTIATION OF 3T3-L2 FIBROBLASTS INTO ADIPOSE-CELLS IN BROMODEOXYURIDINE-SUPPRESSED CULTURES

被引：23

作者：

RUSSELL, TR ^{[1
]}

机构：

[1] UNIV MIAMI,SCH MED,DEPT MED,MIAMI,FL 33136

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 09期

关键词：

D O I：

10.1073/pnas.76.9.4451

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Growth of 3T3-L2 fibroblasts in medium containing 5-bromo-2'-deoxyuridine prevents the spontaneous cytodifferentiation of these cells into adipose cells. Treatment of bromodeoxyuridine-suppressed cultures at confluence with 1-methyl-3-isobutylxanthine, a promoter of the adipose conversion, results in differentiation of the fibroblasts into adipose cells but the extent of the conversion is less than that seen in cultures not treated with bromodeoxyuridine. 1-Methyl-3-isobutylxanthine appears to function without altering the amount of bromodeoxyuridine present in DNA.

引用

页码：4451 / 4454

页数：4

共 22 条

[1]

CHANG TH, 1978, J BIOL CHEM, V253, P4693

[2] DEOXYCYTIDINE REVERSES SUPPRESSION OF PIGMENTATION CAUSED BY 5-BRDURD WITHOUT CHANGING AMOUNT OF 5-BRDURD IN DNA [J].