EFFECTS OF PHOSPHOLIPID AND FACTOR-VA ON THE INHIBITION OF FACTOR-XA BY ANTITHROMBIN-III

被引：48

作者：

WALKER, FJ

ESMON, CT

机构：

[1] Section of Experimental Pathology, Medicine University, Oklahoma Health Sciences Center Oklahoma City

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 90卷 / 02期

关键词：

D O I：

10.1016/0006-291X(79)91283-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The rate of inhibition of Factor Xa by antithrombin III was found to be influenced by either phospholipid or Factor Va combined with phospholipid. Our results confirmed that Factor Va and phospholipid could protect Factor Xa from inhibition. However, when antithrombin III levels were extrapolated to infinity, the protective effect of lipid and Factor Va were eliminated and the rate of inhibition was accelerated. This indicated that the protective effect that was observed at low antithrombin III concentrations in the presence of phospholipid and Factor Va was due to inhibition of binding of the inhibitor to Factor Xa. © 1979.

引用

页码：641 / 647

页数：7

共 29 条

[1]

BLIGH EG, 1959, CAN J BIOCHEM PHYS, V37, P911

[2] BASIC MECHANISMS IN BLOOD-COAGULATION [J].