INHIBITION OF RAT UTERINE CONTRACTIONS BY RAT AND HUMAN CGRP

被引：25

作者：

PENNEFATHER, JN

REYNOLDSON, NA

HANDBERG, GM

机构：

[1] Department of Pharmacology, Monash University, Clayton

来源：

PEPTIDES | 1990年 / 11卷 / 05期

关键词：

Estrogen; Estrous cycle; Field stimulation; Histamine; Human; βCGRP; Isoproterenol; Rat; αCGRP; Stilbestrol; Uterine contractions; Uterine horns; Uterine inhibition;

D O I：

10.1016/0196-9781(90)90006-Q

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Effects of rat and human calcitonin gene-related peptide (rαCGRP and hβCGRP, respectively) upon uterine contractile force were investigated using uterine horns from nonpregnant rats. rαCGRP and hβCGRP were equipotent (pD2=8.85-9.09) in inhibiting spontaneous and electrically evoked uterine contractions. rαCGRP was relatively ineffective in inhibiting potassium-induced contractures of preparations from stilbestrol-pretreated rats. The use of selective antagonists established that rαCGRP did not release prostanoids, or release or act at receptors for catecholamines and histamine. The effects of the peptides were not significantly modulated by estrogen levels since pD2 values were similar (8.56-8.86) in field-stimulated preparations from rats in proestrus/estrus or metestrus/diestrus. © 1990.

引用

页码：903 / 906

页数：4

共 27 条

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