A DOSE-RESPONSE STUDY EXAMINING THE EFFECTS OF RITANSERIN ON HUMAN SLOW-WAVE SLEEP

被引：40

作者：

IDZIKOWSKI, C ^{[1
]}

MILLS, FJ ^{[1
]}

JAMES, RJ ^{[1
]}

机构：

[1] JANSSEN RES FDN,CLIN PHARMACOL UNIT,WANTAGE OX12 0DQ,OXON,ENGLAND

来源：

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 31卷 / 02期

关键词：

RITANSERIN; SLEEP; HUMAN; DOSE-RESPONSE;

D O I：

10.1111/j.1365-2125.1991.tb05514.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study investigated the effects of placebo, 1 mg, 3 mg, 10 mg and 30 mg ritanserin and 10 mg diazepam on human sleep. Twelve normal volunteers participated in this randomized, double-blind, placebo-controlled cross-over sleep study. A clear dose-response relationship was found for ritanserin with higher doses evoking increased duration of slow wave sleep.

引用

页码：193 / 196

页数：4

共 15 条

[1] EFFECTS OF REPEATED RITANSERIN ON MIDDLE-AGED POOR SLEEPERS [J].

ADAM, K ;

OSWALD, I .

PSYCHOPHARMACOLOGY, 1989, 99 (02) :219-221

[2] PHARMACOLOGICAL PROFILE OF RITANSERIN - A VERY SPECIFIC CENTRAL SEROTONIN S2-ANTAGONIST [J].

AWOUTERS, F ;

NIEMEGEERS, CJE ;

MEGENS, AAHP ;

MEERT, TF ;

JANSSEN, PAJ .

DRUG DEVELOPMENT RESEARCH, 1988, 15 (01) :61-73

[3]

CLARENBACH P, 1986, SLEEP RES, V15, P29

[4]

DECLERCK AC, 1987, CURR THER RES CLIN E, V41, P427

[5]

IDZIKOWSKI C, 1987, PSYCHOPHARMACOLOGY, V93, P416

[6] 5-HYDROXYTRYPTAMINE-2 ANTAGONIST INCREASES HUMAN SLOW-WAVE SLEEP [J].

IDZIKOWSKI, C ;

MILLS, FJ ;

GLENNARD, R .

BRAIN RESEARCH, 1986, 378 (01) :164-168

[7]

IDZIKOWSKI C, 1987, SLEEP RES, V16, P93

[8] METHYSERGIDE - SUPPRESSION OF SLEEP-RELATED PROLACTIN SECRETION AND ENHANCEMENT OF SLEEP-RELATED GROWTH-HORMONE SECRETION [J].

MENDELSON, WB ;

JACOBS, LS ;

REICHMAN, JD ;

OTHMER, E ;

CRYER, PE ;

TRIVEDI, B ;

DAUGHADAY, WH .

JOURNAL OF CLINICAL INVESTIGATION, 1975, 56 (03) :690-697

[9] TRAZODONE ENHANCES SLEEP IN SUBJECTIVE QUALITY BUT NOT IN OBJECTIVE DURATION [J].

MONTGOMERY, I ;

OSWALD, I ;

MORGAN, K ;

ADAM, K .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 1983, 16 (02) :139-144

[10]

OSWALD I, 1978, PHARM STATES ALERTNE, P583

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