24-HOUR BLOOD-PRESSURE CONTROL - AN INTRAARTERIAL REVIEW

被引：32

作者：

GOULD, BA

RAFTERY, EB

机构：

[1] and Clinical Research Centre, Harrow, Middlesex

来源：

CHRONOBIOLOGY INTERNATIONAL | 1991年 / 8卷 / 06期

关键词：

24-HOUR BLOOD PRESSURE; BETA-ADRENOCEPTOR BLOCKERS; ALPHA-ADRENOCEPTOR BLOCKERS; VASODILATORS; CALCIUM CHANNEL BLOCKERS; CIRCADIAN RHYTHM;

D O I：

10.3109/07420529109059185

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Intraarterial blood pressure monitoring has shown the circadian rhythm of blood pressure control. Blood pressures tend to be highest in the morning before falling gradually during the day to a nadir at 3:00 a.m. There is a slight rise in the late afternoon that may correspond to patients' attendance at hospital for calibration of the equipment. There is a small rise in the blood pressure before awakening, and after arousal there is a rise in blood pressure to the peak level of the morning. In this article, we examine the effect of a variety of antihypertensive agents on this rhythm. In general, beta-adrenoceptor blockers appear to have less effect on nocturnal blood pressure and surge in pressure after arousal, while vasodilators, particularly alpha-adrenoceptor blockers, have a pronounced effect. These findings indicate that the rise in blood pressure before awakening and the rapid rise upon arousal appear to be due to increased alpha-adrenoceptor activity.

引用

页码：495 / 505

页数：11

共 27 条

[1] Goldberg A.D., Blood pressure and heart rate in ambulatory hypertensives [MD Thesis]., (1976)
[2] Goldberg A.D., Raftery E.B., Patterns of blood pressure during chronic administration of post-ganglionic sympathetic blocking drugs for hypertension, Lancet, 2, pp. 1052-1054, (1976)
[3] Millar-Craig M.W., Kenny D., Mann S., Bala Subramanian V., Raftery E.B., Effect of once daily atenolol on ambulatory blood pressure, Br MedJ, 1, pp. 237-239, (1979)
[4] Millar-Craig M.W., Bishop C.N., Raftery E.B., Circadian variation of blood pressure, Lancet, 1, pp. 795-797, (1978)
[5] Floras J., Fox P., Hassan M.O., Jones J.V., Sleight P., Turner K., Assessment of the antihypertensive effect of atenolol using 24 hour ambulatory monitoring of the blood pressure, CIin Sci, 57, pp. 387s-389s, (1979)
[6] Mehta S., Walsh T., Goldberg D.A., Single daily dosage of acebutulol to control hypertension, Proceedings of the 3rd International Symposium on Ambulatory Monitoring., (1980)
[7] Millar-Craig M.W., Bala Subramanian V., Raftery E.B., Blood pressure circadian rhythm in essential hypertension, Clin Sci Mol Med, 55, pp. 391s-393s, (1978)
[8] Mann S., Millar-Craig M.W., Bala Subramanian V., Melville D., Raftery E.B., The assessment of antihypertensive agents by ambulatory blood pressure monitoring, Viskaldix in the treatment of hypertensiun, (1979)
[9] Mann S., Millar-Craig M.W., Altman D., Melville D., Raftery E.B., The effects of metoprolol on ambulatory blood pressure, CIin Sci, 5, pp. 375s-377s, (1979)
[10] Watson R.D.S., Stallard T.J., Littler W.A., Influence of once daily administration of beta-adrenoceptor antagonists on arterial pressure and its variability, Lancet, l, pp. 1210-1213, (1979)

← 1 2 3 →