CONFORMATIONALLY CONSTRAINED AMINO-ACIDS .2. ON THE SYNTHESIS OF 4-SUBSTITUTED 8-MEMBERED CYCLIC TRYPTOPHAN DERIVATIVES

被引：15

作者：

CHUNG, JYL ^{[1
]}

WASICAK, JT ^{[1
]}

NADZAN, AM ^{[1
]}

机构：

[1] ABBOTT LABS,DEPT 47W,DIV NEUROSCI RES,ABBOTT PK,IL 60064

来源：

SYNTHETIC COMMUNICATIONS | 1992年 / 22卷 / 07期

关键词：

D O I：

10.1080/00397919208019295

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The thermal lactamization of 4-(carboethoxy)-methyl-tryptophan ethyl ester (5), prepared from 4-(carboethoxy)methyl-indole 3 via Gilchrist's method, in refluxing xylene followed by saponification provided the 8-membered cyclic tryptophan derivative 1. Selective reduction of lactam 6 via the iminium ion 9 furnished the cyclic tryptophan derivative 2.

引用

页码：1039 / 1048

页数：10

共 15 条

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