GANGLIOSIDES AS MODULATORS OF CELL-FUNCTION

被引：185

作者：

ZELLER, CB ^{[1
]}

MARCHASE, RB ^{[1
]}

机构：

[1] UNIV ALABAMA, DEPT CELL BIOL, BIRMINGHAM, AL 35294 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY | 1992年 / 262卷 / 06期

关键词：

GLYCOSPHINGOLIPIDS; SYNTHESIS; CELL ADHESION; SIGNAL TRANSDUCTION;

D O I：

10.1152/ajpcell.1992.262.6.C1341

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Gangliosides, sialic acid-containing glycosphingolipids, are found in the outer leaflet of the plasma membrane of all vertebrate tissues and species. This report presents a brief introduction to the gangliosides and reviews the chemistry and topography of their biosynthesis. It also presents an overview of the present evidence supporting a physiological significance for the gangliosides in a variety of experimental systems. This includes consideration of their potential roles in development and cell adhesion. In addition, experimental examples in which gangliosides appear to influence signal transduction processes through their interactions with plasma membrane proteins are discussed.

引用

页码：C1341 / C1355

页数：15

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