CALPEPTIN, A CALPAIN INHIBITOR, PROMOTES NEURITE ELONGATION IN DIFFERENTIATING PC12 CELLS

被引：19

作者：

PINTER, M ^{[1
]}

ASZODI, A ^{[1
]}

FRIEDRICH, P ^{[1
]}

GINZBURG, I ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT NEUROBIOL,IL-76100 REHOVOT,ISRAEL

来源：

NEUROSCIENCE LETTERS | 1994年 / 170卷 / 01期

关键词：

CALPAIN; CALPEPTIN; PC12; NGF; NEURITE GROWTH; DIFFERENTIATION;

D O I：

10.1016/0304-3940(94)90246-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Calpain activity of nerve growth factor (NGF)-induced rat pheochromocytoma (PC12) cells shows a transient diminution in the early phase of differentiation. Calpain activity can be further decreased by a cell-permeable calpain inhibitor, calpeptin, which enhances the effect of NGF by stimulating neurite elongation. The number of neurites sprouted by one cell is not increased by calpeptin. A possible role of calpain inhibition during PC12 cells' early differentiation is discussed.

引用

页码：91 / 93

页数：3

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