SUBCRITICAL FLUID EXTRACTION OF OPIATES IN HAIR OF DRUG-ADDICTS

被引:35
作者
EDDER, P
STAUB, C
VEUTHEY, JL
PIERROZ, I
HAERDI, W
机构
[1] UNIV GENEVA,CMU,INST FORENS MED,CH-1211 GENEVA 4,SWITZERLAND
[2] UNIV GENEVA,PHARM SECT,CH-1211 GENEVA 4,SWITZERLAND
来源
JOURNAL OF CHROMATOGRAPHY B-BIOMEDICAL APPLICATIONS | 1994年 / 658卷 / 01期
关键词
D O I
10.1016/0378-4347(94)00220-7
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Hair analysis is a useful complement to blood and urine analysis in forensic science, but current procedures are tedious and time consuming. Owing to the difficulty of having a sufficient amount of hair in order to perform the optimization of the extraction method, standard hair was made and the procedure is described. The spiking method is reproducible and linearity can be obtained. Subcritical fluid extraction of opiates from standard and drug addicts' hair was optimized (extraction phase composition, extraction time, etc.) and compared with other extraction techniques (basic and acid hydrolysis, organic solvent and enzymatic digestion) followed by solid-phase extraction. Recovery, coefficient of variation, linearity, detection limits and quantification limits for the subcritical fluid extraction of opiates in hair are described.
引用
收藏
页码:75 / 86
页数:12
相关论文
共 20 条
  • [1] DETECTION OF MORPHINE AND MONOACETYLMORPHINE (MAM) IN HUMAN HAIR
    AHRENS, B
    ERDMANN, F
    ROCHHOLZ, G
    SCHUTZ, H
    [J]. FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY, 1992, 344 (12): : 559 - 560
  • [2] ARNOLD W, 1981, J FORENSIC SCI SOC, V21, P83
  • [3] BAUMGARTNER AM, 1979, J NUCL MED, V20, P748
  • [4] BAUMGARTNER WA, 1989, J FORENSIC SCI, V34, P1433
  • [5] CONE EJ, 1990, J ANAL TOXICOL, V14, P1
  • [6] CONE EJ, 1991, J ANAL TOXICOL, V15, P1
  • [7] SUBCRITICAL FLUID EXTRACTION OF MORPHINIC ALKALOIDS IN URINE AND OTHER LIQUID MATRICES AFTER ADSORPTION ON SOLID SUPPORTS
    EDDER, P
    VEUTHEY, JL
    KOHLER, M
    STAUB, C
    HAERDI, W
    [J]. CHROMATOGRAPHIA, 1994, 38 (1-2) : 35 - 42
  • [8] EDDER P, 1992, CHIMIA, V46, P191
  • [9] TESTING HUMAN HAIR FOR DRUGS OF ABUSE .3. IDENTIFICATION OF HEROIN AND 6-ACETYLMORPHINE AS INDICATORS OF HEROIN USE
    GOLDBERGER, BA
    CAPLAN, YH
    MAGUIRE, T
    CONE, EJ
    [J]. JOURNAL OF ANALYTICAL TOXICOLOGY, 1991, 15 (05) : 226 - 231
  • [10] HARKEY MR, 1989, ADV ANAL TOXICOLOGY, V2, P298