FAST DESENSITIZATION OF THE RESPONSE TO INSP3 IN LIMULUS VENTRAL PHOTORECEPTORS

被引：9

作者：

LEVITAN, I ^{[1
]}

HILLMAN, P ^{[1
]}

PAYNE, R ^{[1
]}

机构：

[1] UNIV MARYLAND,DEPT ZOOL,COLL PK,MD 20742

来源：

BIOPHYSICAL JOURNAL | 1993年 / 64卷 / 04期

关键词：

D O I：

10.1016/S0006-3495(93)81470-X

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

In Limulus ventral photoreceptor cells the time-course of the desensitization of InsP3 response was measured by an injection-pair paradigm. Pressure pulses of InsP3 were delivered into the cell with various interpulse intervals. The desensitization of the response to the second injection of each pair approached totality at 200 ms, which is the duration of the response to a single pressure pulse of InsP3. Lowering extracellular calcium did not affect the time-course of the desensitization. Lowering the temperature slowed down both the time-course of the response to InsP3 and the time-course of the desensitization to the same extent. These findings suggest that the desensitization is powerful enough and its onset fast enough to contribute to the transience of the InsP3 response. The time-course of the desensitization suggests it may influence light adaptation.

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页码：1354 / 1360

页数：7

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