INTRALESIONAL INTERFERON-ALPHA AND ZIDOVUDINE IN EPIDEMIC KAPOSIS-SARCOMA

被引：25

作者：

DUPUY, J ^{[1
]}

PRICE, M ^{[1
]}

LYNCH, G ^{[1
]}

BRUCE, S ^{[1
]}

SCHWARTZ, M ^{[1
]}

机构：

[1] BAYLOR COLL MED,DEPT INTERNAL MED,6550 FANNIN,SUITE 1053,HOUSTON,TX 77030

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1993年 / 28卷 / 06期

关键词：

D O I：

10.1016/0190-9622(93)70139-K

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: Kaposi's sarcoma (KS) is the most common neoplasm in patients with acquired immunodeficiency syndrome (AIDS). To date, no therapy has proved to be consistently effective. Objective. The purpose of this study was to evaluate the efficacy of intralesional interferon-alpha in patients with epidemic KS who were taking zidovudine. Methods. Up to five lesions in each of 14 patients entered into the study were injected with 1 million U of interferon-alpha three times weekly for 6 weeks. Sterile water was used as a placebo control. The median zidovudine dose was 500 mg/day. The median CD4 count was 23/mul. Results: Of 14 patients evaluated, 13 of 14 (93%) showed a clinical complete response (CR) or partial response (PR) to therapy. Of 54 lesions injected, 41 (76%) showed a CR and 5 (9%) showed a PR, which resulted in an overall response rate of 85%. Conclusion: Intralesional interferon-alpha produced a high response rate in injected lesions of KS, but it failed to demonstrate superior efficacy over the placebo.

引用

页码：966 / 972

页数：7

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