EFFECT OF NONAPEPTIDE FRAGMENTS OF UTEROGLOBIN AND LIPOCORTIN-I ON EDEMA AND MAST-CELL DEGRANULATION

被引：19

作者：

LLORET, S ^{[1
]}

MORENO, JJ ^{[1
]}

机构：

[1] UNIV BARCELONA, FAC FARM, DEPT CIENCIAS FISIOL HUMANAS & NUTR, FISIOL LAB, E-08028 BARCELONA, SPAIN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 264卷 / 03期

关键词：

ANTIFLAMMIN; PHOSPHOLIPASE A(2); INFLAMMATION; MAST CELL DEGRANULATION; ANTIINFLAMMATORY DRUG;

D O I：

10.1016/0014-2999(94)00500-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The anti-inflammatory action of nonapeptide fragments of uteroglobin or lipocortin I known as antiflammins, was tested in the carrageenan or phospholipase A(2) rat paw oedema model. The development of carrageenan-induced oedema in rats was significantly inhibited during the early and late phases of the oedema by the local administration of antiflammins 1 and 2. However, the peptides were not able to inhibit phospholipase A(2)-induced oedema. The time course of the anti-oedematous activity of nonapeptides after intradermal carrageenan injection may be attributed to their effect on mast cell degranulation and accumulation and activation of leukocytes. Naja naja phospholipase A(2) exhibited strong histamine release-inducing activity, which may have contributed to the rat paw oedema induction. Surprisingly, antiflammins had a limited but significant inhibitory effect on histamine secretion.

引用

页码：379 / 384

页数：6

共 31 条

[1] ACTIVATION OF PHOSPHOINOSITIDE HYDROLYSIS BY NERVE GROWTH-FACTOR AND LYSOPHOSPHATIDYLSERINE IN RAT PERITONEAL MAST-CELLS [J].