VISUALIZATION OF SUPERIOR MESENTERIC LYMPH-NODES BY THE COMBINED ORAL AND INTRAVENOUS ADMINISTRATION OF THE ULTRASMALL SUPERPARAMAGNETIC IRON-OXIDE, AMI-227

被引：10

作者：

ROGERS, JM

LEWIS, J

JOSEPHSON, L

机构：

[1] Advanced Magnetics Inc., Cambridge, MA 02138

来源：

MAGNETIC RESONANCE IMAGING | 1994年 / 12卷 / 08期

关键词：

CONTRAST MEDIA; LYMPH NODES; SUPERIOR MESENTERIC; ULTRASMALL SUPERPARAMAGNETIC IRON OXIDE; ORAL; INTRAVENOUS;

D O I：

10.1016/0730-725X(94)90081-2

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Superior mesenteric lymph nodes which lie as a chain near the small intestine are difficult to visualize in the rat with MRI either with or without the use of contrast agents. We previously demonstrated that the oral administration of an ultrasmall superparamagnetic iron oxide (AMI-227) produces a brightening of the lumen of the GI tract with a T-1-weighted spin-echo pulse sequence. We have also shown that AMI-227 darkens abdominal lymph nodes. In the present study we show that the combined oral and intravenous administration of AMI-227 produces a brightening of the lumen of the GI tract and a darkening of the superior mesenteric lymph node chain. As a result of these combined and opposing effects on image signal intensity, a necessary contrast is established to reliably locate the superior mesenteric lymph nodes in vivo, which, to our knowledge,have been elusive by other techniques.

引用

页码：1161 / 1165

页数：5

共 11 条

[1] Anzai, Blackwell, McLachlan, Fu, Abemayor, Lufkin, Initial clinical experience with an iron-based MR imaging contrast agent for lymph nodes, Radiol. Soc. North Am. Abstract #20C, (1993)
[2] Hamm, Wolf, Contrast material for computed tomography and magnetic resonance imaging of the gastrointestinal tract, Curr. Opin. Radiol., 3, pp. 474-482, (1991)
[3] Hahn, Advances in contrast-enhanced MR imaging: Gastrointestinal contrast agents, Am. J. Roentgenol., 156, pp. 252-254, (1991)
[4] Laniado, Kornmesser, Hamm, Clauss, Weinmann, Felix, MR imaging of the gastrointestinal tract: Value of Gd-DTPA, Am. J. Roentgenol, 150, pp. 817-821, (1988)
[5] Rinck, Smevik, Nilsen, Klepp, Onsrud, Oksendal, Borseth, Oral magnetic particles in MR imaging of the abdomen and pelvis, Radiology, 178, pp. 775-779, (1991)
[6] Hahn, Stark, Lewis, Saini, Elizondo, Weissleder, Fretz, Ferrucci, First clinical trial of a new superparamagnetic iron oxide for use as an oral gastrointestinal contrast agent in MR imaging, Radiology, 175, pp. 695-700, (1990)
[7] Rogers, Lewis, Josephson, The use of AMI-227 as an oral MR contrast agent, Magn. Reson. Imaging, 12, pp. 631-639, (1994)
[8] Palmacci, Josephson, Synthesis of polysaccharide covered superparamagnetic oxide colloids, (1993)
[9] Bengele, Palmacci, Rogers, Jung, Crenshaw, Josephson, The biodistribution of an ultrasmall superparamagnetic iron oxide colloid, AMI-227, by different routes of administration, Magn. Reson. Imaging, 12, pp. 433-442, (1994)
[10] Small, Nelson, Bernadino, Dual contrast enhancement of both T<sub>1</sub>- and T<sub>2</sub>-weighted sequences using ultrasmall superparamagnetic iron oxide, Magn. Reson. Imaging, 11, pp. 645-654, (1993)

← 1 2 →