ENZYMATIC HYDROLYZES OF THE SIGMA-SYMMETRICAL DICARBOXYLIC DIESTERS BEARING A SULFINYL GROUP AS THE PROCHIRAL CENTER

被引:18
作者
TAMAI, S
MIYAUCHI, S
MORIZANE, C
MIYAGI, K
SHIMIZU, H
KUME, M
SANO, S
SHIRO, M
NAGAO, Y
机构
[1] UNIV TOKUSHIMA, FAC PHARMACEUT SCI, TOKUSHIMA 770, JAPAN
[2] KYOTO UNIV, CHEM RES INST, UJI, KYOTO 611, JAPAN
[3] RIGAKU CORP, AKISHIMA, TOKYO 196, JAPAN
关键词
D O I
10.1246/cl.1994.2381
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Enzymatic hydrolyses of the sigma-symmetric dicarboxylic diesters bearing a sulfinyl group as the prochiral center were examined by employing porcine liver esterase and procine pancreatic lipase. Eventually, their chiral half esters were elaborately obtained as the corresponding chiral phenacyl esters. The stereochemistry of the chiral half esters was determined by the X-ray analysis and their chemical correlations.
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页码:2381 / 2384
页数:4
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