MATURATION AND MIGRATION OF CUTANEOUS DENDRITIC CELLS

被引:73
作者
STEINMAN, R [1 ]
HOFFMAN, L [1 ]
POPE, M [1 ]
机构
[1] CORNELL UNIV,COLL MED,DIV PLAST SURG,NEW YORK,NY
关键词
HIV-1; MEMORY T CELLS; GM-CSF; DENDRITIC-T-CELL CONJUGATES;
D O I
10.1111/1523-1747.ep12315162
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Dendritic cells have been isolated from the epidermis, dermis, and lymphatics of kin, Cells from each cutaneous compartment can exhibit the distinct morphology, surface phenotype, and strong T-cell-stimulating activity of dendritic cells that are isolated from other organs, Of importance are the mechanisms by which the maturation and movement of dendritic cells are regulated within intact tissues, Epidermal dendritic cells turn over slowly in the steady state, Stimuli, including contact allergens and transplantation, perhaps by including a release of cytokines such as granulocyte macrophage-colony-stimulating factor, mobilize these dendritic cells into the dermis and lymph, This migration is accompanied by the maturation of dendritic cell functions; e.g., antigen-presenting major histocompatibility complex molecules and B7 costimulators increase markedly, On the other hand, there is a sizable, steady-state flux of dendritic cells in afferent lymph draining the skin, which suggests a constant traffic through the dermis that is independent of sessile epidermal dendritic cells, When explants of skin are placed in organ culture, dendritic cells emigrate into the medium for 1-3 d, The dendritic cells are mature and can bind tightly to small memory T cells that also migrate in these cultures, The emigrated mixtures of dendritic cells and T cells should be useful in the study of many clinical states, This is illustrated by recent experiments showing that migratory skin cells are readily infected with human immunodeficiency virus (HIV)-1, A strong productive infection takes place in the absence of exogenous cytokines, foreign sera, or mitogens or antigens, The dendritic cell-T-cell conjugates are the essential site for infection, This cellular milieu may model events during the sexual transmission of HIV-1, where relevant mucosal surfaces are covered by skin-like epithelia. The capture of CD4(+) memory T cells by dendritic cells may explain the chronic drain of immune memory in HTV infection.
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页码:S2 / S7
页数:6
相关论文
共 89 条
[1]  
AUSTYN JM, 1994, J IMMUNOL, V152, P2401
[2]   MIGRATION PATTERNS OF DENDRITIC LEUKOCYTES - IMPLICATIONS FOR TRANSPLANTATION [J].
AUSTYN, JM ;
LARSEN, CP .
TRANSPLANTATION, 1990, 49 (01) :1-7
[3]   LARGE INCREASE OF LANGERHANS CELLS IN HUMAN SKIN LYMPH DERIVED FROM IRRITANT CONTACT-DERMATITIS [J].
BRAND, CU ;
HUNZIKER, T ;
LIMAT, A ;
BRAATHEN, LR .
BRITISH JOURNAL OF DERMATOLOGY, 1993, 128 (02) :184-188
[4]   CHARACTERIZATION OF SHEEP AFFERENT LYMPH DENDRITIC CELLS AND THEIR ROLE IN ANTIGEN CARRIAGE [J].
BUJDOSO, R ;
HOPKINS, J ;
DUTIA, BM ;
YOUNG, P ;
MCCONNELL, I .
JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (04) :1285-1302
[5]   ACTIVATION OF HUMAN DENDRITIC CELLS THROUGH CD40 CROSS-LINKING [J].
CAUX, C ;
MASSACRIER, C ;
VANBERVLIET, B ;
DUBOIS, B ;
VANKOOTEN, C ;
DURAND, I ;
BANCHEREAU, J .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (04) :1263-1272
[6]  
CAUX C, 1991, BLOOD, V78, P635
[7]   B70/B7-2 IS IDENTICAL TO CD86 AND IS THE MAJOR FUNCTIONAL LIGAND FOR CD28 EXPRESSED ON HUMAN DENDRITIC CELLS [J].
CAUX, C ;
VANBERVLIET, B ;
MASSACRIER, C ;
AZUMA, M ;
OKUMURA, K ;
LANIER, LL ;
BANCHEREAU, J .
JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 180 (05) :1841-1847
[8]   GM-CSF AND TNF-ALPHA COOPERATE IN THE GENERATION OF DENDRITIC LANGERHANS CELLS [J].
CAUX, C ;
DEZUTTERDAMBUYANT, C ;
SCHMITT, D ;
BANCHEREAU, J .
NATURE, 1992, 360 (6401) :258-261
[9]   OCCURRENCE OF DONOR LANGERHANS CELLS IN MOUSE AND RAT CHIMERAS AND THEIR REPLACEMENT IN SKIN-GRAFTS [J].
CHEN, HD ;
MA, CL ;
YUAN, JT ;
WANG, YK ;
SILVERS, WK .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1986, 86 (06) :630-633
[10]   DENDRITIC CELLS ARE THE PRINCIPAL CELLS IN MOUSE SPLEEN BEARING IMMUNOGENIC FRAGMENTS OF FOREIGN PROTEINS [J].
CROWLEY, M ;
INABA, K ;
STEINMAN, RM .
JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (01) :383-386