PATTERN OF NEUROBEHAVIORAL DEFICITS ASSOCIATED WITH INTERFERON-ALFA THERAPY FOR LEUKEMIA

被引：136

作者：

PAVOL, MA

MEYERS, CA

REXER, JL

VALENTINE, AD

MATTIS, PJ

TALPAZ, M

机构：

[1] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT NEUROONCOL,HOUSTON,TX 77030

[2] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT CLIN IMMUNOL & BIOL THERAPY,HOUSTON,TX 77030

来源：

NEUROLOGY | 1995年 / 45卷 / 05期

关键词：

D O I：

10.1212/WNL.45.5.947

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We evaluated the neuropsychological and personality profiles of 25 patients with chronic myelogenous leukemia treated with interferon alfa (IFN-alpha). This group of persons performed well below expectation on tests of cognitive speed, verbal memory, and executive functions. Personality changes included depression, increased somatic concern, and stress reactions. A control group of leukemia patients not treated with IFN-alpha had significantly better cognitive speed and mood. The pattern of cognitive and personality changes in patients receiving IFN-alpha is highly suggestive of frontal-subcortical brain dysfunction.

引用

页码：947 / 950

页数：4

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