INDUCTION OF DRUG-METABOLIZING ENZYMES IN LIVER MICROSOMES OF MICE AND RATS BY SOFTWOOD BEDDING

被引：123

作者：

VESELL, ES

机构：

来源：

SCIENCE | 1967年 / 157卷 / 3792期

关键词：

D O I：

10.1126/science.157.3792.1057

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Induction of 3 drug-metabolizing enzymes occurred in liver microsomes of mice and rats kept on softwood bedding of either red cedar, white pine, or ponderosa pine. This induction was reversed when animals were placed on hardwood bedding composed of a mixture of beech, birch, and maple. Differences in the capacity of various beddings to induce may partially explain divergent results of studies on drug-metabolizing enzymes. The presence of such indicing substances in the environment may influence the pharmacologic responsiveness of animals to a wide variety of drugs.

引用

页码：1057 / +

页数：1

共 7 条

[1]

COOPER JR, 1955, J PHARMACOL EXP THER, V114, P409

[2] EFFECT OF RED CEDAR CHIP BEDDING ON HEXOBARBITAL AND PENTOBARBITAL SLEEP TIME [J].