COMPLETE AMINO-ACID-SEQUENCE OF A CANINE MU CHAIN

被引：8

作者：

MCCUMBER, LJ

CAPRA, JD

机构：

[1] Department of Microbiology, The University of Texas Health Science Center at Dallas, Southwestern Medical School, Dallas

来源：

MOLECULAR IMMUNOLOGY | 1979年 / 16卷 / 08期

关键词：

D O I：

10.1016/0161-5890(79)90119-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The amino-acid sequence of the CH1 and the CH2 domains of a canine mu chain has been determined, completing the primary structural analysis of this molecule. The result extends our previous conclusions concerning the remarkably high degree of interspecies homology to human IgM, as the canine CH1 and CH2 domains are 81 and 72% homologous to their human counterparts. The overall homology of the entire constant region of the canine mu chain to the human mu chain is 81%. This study represents the first complete primary structure of a non-IgG heavy chain from a species other than man. © 1979.

引用

页码：565 / 570

页数：6

共 21 条

[1] DETERMINATION OF PRIMARY STRUCTURE OF A MOUSE IGG2A IMMUNOGLOBULIN - AMINO-ACID SEQUENCE OF FC FRAGMENT [J].

BOURGOIS, A ;

FOUGEREAU, M ;

ROCCASER.J .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1974, 43 (03) :423-435

[2]

Capra J.D., 1976, P65

[3]

CAPRA JD, 1977, J IMMUNOL, V119, P993

[4] AMINO ACID SEQUENCE SIMILARITIES IN 2 HUMAN ANTI GAMMA GLOBULIN ANTIBODIES [J].

CAPRA, JD ;

KUNKEL, HG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1970, 67 (01) :87-+

[5] PHYLOGENETICALLY ASSOCIATED RESIDUES WITHIN VHIII SUBGROUP OF SEVERAL MAMMALIAN SPECIES - EVIDENCE FOR A PAUCI-GENE BASIS FOR ANTIBODY DIVERSITY [J].

CAPRA, JD ;

WASSERMAN, RL ;

KEHOE, JM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1973, 138 (02) :410-427

[6]

CAPRA JD, 1977, ANTIBODIES HUMAN DIA, P87

[7] EVOLUTIONARY RELATIONSHIP BETWEEN CARBOXYTERMINAL REGION OF A HUMAN ALPHA-CHAIN AND OTHER IMMUNOGLOBULIN HEAVY-CHAIN CONSTANT REGIONS [J].

CHUANG, CY ;

CAPRA, JD ;

KEHOE, JM .

NATURE, 1973, 244 (5412) :158-160

[8] IMMUNOLOGICAL ACTIVITY OF SOME OF CHYMOTRYPTIC PEPTIDES OF SPERM-WHALE MYOGLOBIN [J].

CRUMPTON, MJ ;

WILKINSO.JM .

BIOCHEMICAL JOURNAL, 1965, 94 (03) :545-&

[9] COVALENT STRUCTURE OF A HUMAN GAMMAG-IMMUNOGLOBULIN .7. AMINO ACID SEQUENCE OF HEAVY-CHAIN CYANOGEN BROMIDE FRAGMENTS H1-H4 [J].

CUNNINGHAM, BA ;

RUTISHAUSER, U ;

GALL, WE ;

GOTTLIEB, PD ;

WAXDAL, MJ ;

EDELMAN, GM .

BIOCHEMISTRY, 1970, 9 (16) :3161-+

[10]

GALLY JA, 1973, ANTIGENS, V1, P161

← 1 2 3 →