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MASTOPARAN, A WASP VENOM, ACTIVATES PLATELETS VIA PERTUSSIS TOXIN-SENSITIVE GTP-BINDING PROTEINS

被引：62
作者：
OZAKI, Y
MATSUMOTO, Y
YATOMI, Y
HIGASHIHARA, M
KARIYA, T
KUME, S
机构：
[1] SAGA MED COLL,DEPT INTERNAL MED,SAGA,JAPAN
[2] UNIV TOKYO,FAC MED,DEPT INTERNAL MED 1,TOKYO 113,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 170卷 / 02期
关键词：
D O I：
10.1016/0006-291X(90)92159-W
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Mastoparan induced limited release of serotonin from intact human platelets, while neither intracellular calcium ion elevation nor arachidonic acid mobilization was observed. Cytolysis induced by mastoparan was negligible in the concentration range that induced serotonin release. In digitonin-permeabilized cells, mastoparan induced Ca++-independent release of serotonin and Ca++-dependent arachidonic acid release. Both serotonin release and arachidonic acid release were reduced by pertussis toxin, suggesting that platelet activation induced by mastoparan is mediated by GTP-binding proteins. © 1990.
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页码：779 / 785
页数：7
相关论文
共 14 条
[1]  
ANGIOLAS A, 1983, J BIOL CHEM, V258, P13697
[2]   CALMODULIN AND TROPONIN-C - A COMPARATIVE-STUDY OF THE INTERACTION OF MASTOPARAN AND TROPONIN-I INHIBITORY PEPTIDE [104-115] [J].
CACHIA, PJ ;
VANEYK, J ;
INGRAHAM, RH ;
MCCUBBIN, WD ;
KAY, CM ;
HODGES, RS .
BIOCHEMISTRY, 1986, 25 (12) :3553-3562
[3]  
HIGASHIJIMA T, 1988, J BIOL CHEM, V263, P6491
[4]  
HIGASHIJIMA T, 1987, PEPTIDE CHEM 1986, P75
[5]  
HIRAI Y, 1979, CHEM PHARM BULL, V27, P1942
[6]   PERTUSSIS TOXIN-SENSITIVE GTP-BINDING PROTEINS MAY REGULATE PHOSPHOLIPASE-A2 IN RESPONSE TO THROMBIN IN RABBIT PLATELETS [J].
KAJIYAMA, Y ;
MURAYAMA, T ;
NOMURA, Y .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1989, 274 (01) :200-208
[7]   DIFFERENTIAL SENSITIVITY OF ARACHIDONIC-ACID RELEASE AND 1,2-DIACYLGLYCEROL FORMATION TO PERTUSSIS TOXIN, GDP-BETA-S AND NAF IN SAPONIN-PERMEABILIZED HUMAN-PLATELETS - POSSIBLE EVIDENCE FOR DISTINCT GTP-BINDING PROTEINS INVOLVING PHOSPHOLIPASE-C AND A2 ACTIVATION [J].
NAKASHIMA, S ;
HATTORI, H ;
SHIRATO, L ;
TAKENAKA, A ;
NOZAWA, Y .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1987, 148 (03) :971-978
[8]   PRIMARY ROLE OF CALCIUM-IONS IN ARACHIDONIC-ACID RELEASE FROM RAT PLATELET MEMBRANES - COMPARISON WITH HUMAN-PLATELET MEMBRANES [J].
NAKASHIMA, S ;
SUGANUMA, A ;
MATSUI, A ;
HATTORI, H ;
SATO, M ;
TAKENAKA, A ;
NOZAWA, Y .
BIOCHEMICAL JOURNAL, 1989, 259 (01) :139-144
[9]  
OHTA H, 1985, J BIOL CHEM, V260, P5771
[10]   A WASP VENOM MASTOPARAN-INDUCED POLYPHOSPHOINOSITIDE BREAKDOWN IN RAT PERITONEAL MAST-CELLS [J].
OKANO, Y ;
TAKAGI, H ;
TOHMATSU, T ;
NAKASHIMA, S ;
KURODA, Y ;
SAITO, K ;
NOZAWA, Y .
FEBS LETTERS, 1985, 188 (02) :363-366
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