AMPEROZIDE - EFFECT ON PROLACTIN-RELEASE IN THE RAT

被引：11

作者：

ALBINSSON, A

ERIKSSON, E

ANDERSSON, G

机构：

[1] Pharmacia Leo Therapeutics Ab, Department of Cns-Research, Malmö, S-201 80

来源：

PHARMACOLOGY & TOXICOLOGY | 1990年 / 66卷

关键词：

D O I：

10.1111/j.1600-0773.1990.tb01607.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Amperozide, a new putatively antipsychotic drug was investigated for its effect on prolactin release in the rat. A significant decrease in the plasma concentration of prolactin was found at 30 minutes after treatment with amperozide. However, there was no effect of amperozide on prolactin release from isolated pituitary cells. These results suggest that there is no direct effect of amperozide on the pituitary lactotrophs and that the attenuation of prolactin secretion in vivo is mediated at a higher level. 1990 Nordic Pharmacological Society

引用

页码：49 / 51

页数：3

共 11 条

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