INHIBITION OF INTERLEUKIN-1-INDUCED COLLAGENASE PRODUCTION IN HUMAN ARTICULAR CHONDROCYTES INVITRO BY RECOMBINANT HUMAN INTERFERON-GAMMA

被引：33

作者：

ANDREWS, HJ ^{[1
]}

BUNNING, RAD ^{[1
]}

PLUMPTON, TA ^{[1
]}

CLARK, IM ^{[1
]}

RUSSELL, RGG ^{[1
]}

CAWSTON, TE ^{[1
]}

机构：

[1] UNIV SHEFFIELD,SCH MED,DEPT HUMAN METAB & CLIN BIOCHEM,SHEFFIELD S10 2TN,S YORKSHIRE,ENGLAND

来源：

ARTHRITIS AND RHEUMATISM | 1990年 / 33卷 / 11期

关键词：

D O I：

10.1002/art.1780331119

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The production of collagenase by human articular chondrocytes in response to interleukin‐1β is inhibited in a dose‐dependent manner by interferon‐γ (1–1,000 units/ml). The analysis of culture medium samples by Western blotting and the measurement of levels of tissue inhibitor of metalloproteinases suggest that the decrease in measurable collagenase activity is primarily due to the inhibition of procollagenase production. These results provide evidence of a role for interferon‐γ in limiting connective tissue degradation. Copyright © 1990 American College of Rheumatology

引用

页码：1733 / 1738

页数：6

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