AN INVESTIGATION OF THE ANABOLIC ACTIVITY OF SOMATROPIN IN NORMAL AND BURNED RATS

被引：10

作者：

BELCHER, HJCR

ELLIS, H

机构：

[1] Surgical Unit, Westminster Hospital, London

来源：

BURNS | 1990年 / 16卷 / 01期

关键词：

D O I：

10.1016/0305-4179(90)90200-G

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

A 'blind', cross-over study was performed in 10 control and 12 burned rats which were assigned to receive either biosynthetic human growth hormone (somatropin) or placebo for 5 days each in random order. There was a significant use in urinary nitrogen excretion and rapid weight loss in the burned rats, which also had significantly lower plasma somatomedin levels than control rats. Somatropin administration resulted in a significant increase in somatomedin levels in control rats only. There was no significant difference in weight or nitrogen balance between somatropin or placebo-treated rats. It is concluded that rats with normal pituitary function are insensitive to the anabolic effects of somatropin and that burn injury abolishes the normal somatomedin response to somatropin. © 1990.

引用

页码：17 / 20

页数：4

共 17 条

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