PRESENCE OF HTLV-I PROVIRAL DNA IN CENTRAL-NERVOUS-SYSTEM OF PATIENTS WITH HTLV-I-ASSOCIATED MYELOPATHY

被引:88
作者
KIRA, J
ITOYAMA, Y
KOYANAGI, Y
TATEISHI, J
KISHIKAWA, M
AKIZUKI, S
KOBAYASHI, I
TOKI, N
SUEISHI, K
SATO, H
SAKAKI, Y
YAMAMOTO, N
GOTO, I
机构
[1] TOKYO MED & DENT UNIV,DEPT MICROBIOL,TOKYO 113,JAPAN
[2] TOKYO WOMENS MED COLL,DEPT NEUROL,TOKYO 162,JAPAN
[3] MED COLL OITA,DEPT PATHOL,OITA 87956,JAPAN
[4] NAGASAKI UNIV,DEPT PATHOL,NAGASAKI 852,JAPAN
[5] KYUSHU UNIV,INST NEUROL,DEPT NEUROPATHOL,FUKUOKA 812,JAPAN
[6] KYUSHU UNIV,DEPT PATHOL,FUKUOKA 812,JAPAN
[7] KYUSHU UNIV,FAC MED,CENT LAB,FUKUOKA 812,JAPAN
[8] KYUSHU UNIV,GENET INFORMAT RES LAB,FUKUOKA 812,JAPAN
关键词
D O I
10.1002/ana.410310108
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The polymerase chain reaction (PCR) method was used to determine the presence and amount of human T lymphotropic virus type I (HTLV-I) proviral DNA in central nervous system (CNS) tissue obtained at autopsy from 6 patients with HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP), 1 patient with adult T-cell leukemia (ATL) and CNS infiltration of leukemic cells, and 9 control subjects with other neurological disorders. HTLV-I pX and env but not pol DNA were detected in CNS tissue from 5 of 6 patients with HAM/TSP. The ATL samples were positive for pX, env, and pol DNA by PCR. None of the control samples was consistently positive for HTLV-I by PCR, but all showed positive bands on beta-globin PCR. Quantitative PCR combined with histological studies showed no correlation between HTLV-I proviral DNA amounts and extent of perivascular mononuclear cell infiltration in the HAM/TSP CNS. Also, the amounts of pX and probably env DNA were greater in the HAM/TSP samples than in the ATL sample, although the extent of mononuclear cell infiltration was far less in the HAM/TSP samples than in the ATL sample. Therefore, in addition to infiltrating mononuclear cells, constituent cells of the CNS may harbor the HTLV-I genome, at least in the pX and env regions, in patients with HAM/TSP.
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页码:39 / 45
页数:7
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