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ANTITUSSIVE EFFECTS OF CA2+ CHANNEL ANTAGONISTS

被引：31
作者：
KAMEI, J
KASUYA, Y
机构：
[1] Department of Pharmacology, School of Pharmacy, Hoshi University, Shinagawa-ku, Tokyo, 142, 4-41
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 212卷 / 01期
关键词：
COUGH REFLEX; CA2+ CHANNELS; ANTITUSSIVE EFFECT; FLUNARIZINE; NIFEDIPINE; VERAPAMIL;
D O I：
10.1016/0014-2999(92)90072-C
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of Ca2+ channel antagonists on the capsaicin-induced cough reflex in guinea pigs were studied. Intraperitoneal injection of nifedipine, verapamil and flunarizine in doses that ranged from 0.3 to 3.0 mg/kg decreased the number of coughs in a dose-dependent manner. These Ca2+ channel antagonists exhibited antitussive effects in the following order of potency: flunarizine = verapamil > nifedipine. Pretreatment with a low dose of nifedipine (0.3 mg/kg), which by itself had no significant effect on the number of coughs, markedly increased the antitussive effects of morphine, dihydrocodeine and dextromethorphan. These data suggest that Ca2+ channels play an important role in the regulation of the cough reflex.
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页码：61 / 66
页数：6
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