EXPRESSION OF THE RECEPTOR FOR MACROPHAGE-COLONY-STIMULATING FACTOR BY BRAIN MICROGLIA AND ITS UP-REGULATION IN BRAINS OF PATIENTS WITH ALZHEIMERS-DISEASE AND AMYOTROPHIC-LATERAL-SCLEROSIS

被引：124

作者：

AKIYAMA, H

NISHIMURA, T

KONDO, H

IKEDA, K

HAYASHI, Y

MCGEER, PL

机构：

[1] YOKOHAMA CITY UNIV,DEPT PSYCHIAT,YOKOHAMA,KANAGAWA,JAPAN

[2] MORINAGA MILK IND CO LTD,BIOCHEM RES INST,ZAMA,JAPAN

[3] UNIV BRITISH COLUMBIA,KINSMEN LAB NEUROL RES,VANCOUVER V6T 1W5,BC,CANADA

来源：

BRAIN RESEARCH | 1994年 / 639卷 / 01期

关键词：

MICROGLIA; MACROPHAGE COLONY STIMULATING FACTOR; RECEPTOR; ALZHEIMERS DISEASE;

D O I：

10.1016/0006-8993(94)91779-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The receptor for macrophage colony stimulating factor (CSF-1) was localized immunohistochemically in postmortem human brain tissue. Microglia constitutively expressed the receptor for CSF-1 and its expression was upregulated in lesions of Alzheimer's disease and amyotrophic lateral sclerosis. The CSF-1 mediated pathway appears to be involved in the response and activation of microglia in the central nervous system lesions.

引用

页码：171 / 174

页数：4

共 16 条

[1] BRAIN MICROGLIA CONSTITUTIVELY EXPRESS BETA-2 INTEGRINS [J].