THERAPEUTIC POTENTIAL OF EXCITATORY AMINO-ACID ANTAGONISTS - CHANNEL BLOCKERS AND 2,3-BENZODIAZEPINES

被引：301

作者：

ROGAWSKI, MA

机构：

[1] M. A. Rogaski is Chif of the Neuronal Excitability Section, Epilepsy Research Branch, Division of Intramural Research, Bethesda, MD

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1993年 / 14卷 / 09期

关键词：

D O I：

10.1016/0165-6147(93)90005-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

NMDA and non-NMDA (AMPA/kainate) antagonists have potential in the treatment of a diverse group of neurological disorders associated with excessive activation of excitatory amino acid receptors. Here Michael Rogawski reviews recent progress in the development of therapeutically useful NMDA receptor channel blockers and a new class of selective AMPA/kainate receptor antagonists, the 2,3-benzodiazepines. Research on these novel noncompetitive excitatory amino acid antagonists has opened promising new avenues for the development of drugs to treat epilepsy, ischaemia, neurogeneration and Parkinson's disease.

引用

页码：325 / 331

页数：7

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