MELATONIN STIMULATES BRAIN GLUTATHIONE-PEROXIDASE ACTIVITY

被引：524

作者：

BARLOWWALDEN, LR ^{[1
]}

REITER, RJ ^{[1
]}

ABE, M ^{[1
]}

PABLOS, M ^{[1
]}

MENENDEZPELAEZ, A ^{[1
]}

CHEN, LD ^{[1
]}

POEGGELER, B ^{[1
]}

机构：

[1] UNIV TEXAS,HLTH SCI CTR,DEPT CELLULAR & STRUCT BIOL,SAN ANTONIO,TX 78284

来源：

NEUROCHEMISTRY INTERNATIONAL | 1995年 / 26卷 / 05期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0197-0186(94)00154-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exogenously administered melatonin causes a 2-fold rise in glutathione peroxidase activity within 30 min in the brain of the rat. Furthermore, brain glutathione peroxidase activity is higher at night than during the day and is correlated with high night-time tissue melatonin levels. Glutathione peroxidase is thought to be the principal enzyme eliminating peroxides in the brain. This antioxidative enzyme reduces the formation of hydroxyl hydroxyl radicals formed via iron-catalyzed Fenton-type reactions from hydrogen peroxide by reducing this oxidant to water. Since the hydroxyl radical is the most noxious oxygen radical known, induction of brain glutathione peroxidase might be an important mechanism by which melatonin exerts its potent neuroprotective effects.

引用

页码：497 / 502

页数：6

共 30 条

[1] NEUROCHEMICAL ASPECTS OF AGING IN PRIMATES
BEAL, MF
[J]. NEUROBIOLOGY OF AGING, 1993, 14 (06) : 707 - 709
[2] PREVENTION OF MICROSOMAL PRODUCTION OF HYDROXYL RADICALS, BUT NOT LIPID-PEROXIDATION, BY THE GLUTATHIONE-GLUTATHIONE PEROXIDASE SYSTEM
BELOQUI, O
CEDERBAUM, AI
[J]. BIOCHEMICAL PHARMACOLOGY, 1986, 35 (16) : 2663 - 2669
[3] CONCURRENT DETERMINATION OF ENZYMATIC-ACTIVITIES AND SUBSTRATE CONCENTRATIONS IN THE MELATONIN SYNTHETIC PATHWAY WITHIN THE SAME RAT PINEAL-GLAND
CHAMPNEY, TH
HOLTORF, AP
STEGER, RW
REITER, RJ
[J]. JOURNAL OF NEUROSCIENCE RESEARCH, 1984, 11 (01) : 59 - 66
[4] MELATONIN PREVENTS THE SUPPRESSION OF CARDIAC CA2+-STIMULATED ATPASE ACTIVITY-INDUCED BY ALLOXAN
CHEN, LD
KUMAR, P
REITER, RJ
TAN, DX
MANCHESTER, LC
CHAMBERS, JP
POEGGELER, B
SAARELA, S
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 267 (01): : E57 - E62
[5] INVIVO AND INVITRO EFFECTS OF THE PINEAL-GLAND AND MELATONIN ON [CA2++MG2+]-DEPENDENT ATPASE IN CARDIAC SARCOLEMMA
CHEN, LD
TAN, DX
REITER, RJ
YAGA, K
POEGGELER, B
KUMAR, P
MANCHESTER, LC
CHAMBERS, JP
[J]. JOURNAL OF PINEAL RESEARCH, 1993, 14 (04) : 178 - 183
[6] CU/ZN SUPEROXIDE-DISMUTASE MESSENGER-RNA AND ENZYME-ACTIVITY, AND SUSCEPTIBILITY TO LIPID-PEROXIDATION, INCREASES WITH AGING IN MURINE BRAINS
DEHAAN, JB
NEWMAN, JD
KOLA, I
[J]. MOLECULAR BRAIN RESEARCH, 1992, 13 (03): : 179 - 187
[7] PROTECTION BY DIHYDROERGOCRYPTINE OF GLUTAMATE-INDUCED NEUROTOXICITY
FAVIT, A
SORTINO, MA
ALEPPO, G
SCAPAGNINI, U
CANONICO, PL
[J]. PHARMACOLOGY & TOXICOLOGY, 1993, 73 (04): : 224 - 228
[8] FRASER S, 1983, CLIN CHEM, V29, P396
[9] THE SIGNIFICANCE OF THE METABOLISM OF THE NEUROHORMONE MELATONIN - ANTIOXIDATIVE PROTECTION AND FORMATION OF BIOACTIVE SUBSTANCES
HARDELAND, R
REITER, RJ
POEGGELER, B
TAN, DX
[J]. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1993, 17 (03) : 347 - 357
[10] EUTHANASIA BY DECAPITATION - EVIDENCE THAT THIS TECHNIQUE PRODUCES PROMPT, PAINLESS UNCONSCIOUSNESS IN LABORATORY RODENTS
HOLSON, RR
[J]. NEUROTOXICOLOGY AND TERATOLOGY, 1992, 14 (04) : 253 - 257

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