RAPID AND EFFICIENT STEREOCONTROLLED SYNTHESIS OF C-3'-ETHYNYL RIBO AND XYLONUCLEOSIDES BY ORGANOCERIUM ADDITIONS TO 3'-KETONUCLEOSIDES

被引：34

作者：

JUNG, PMJ ^{[1
]}

BURGER, A ^{[1
]}

BIELLMANN, JF ^{[1
]}

机构：

[1] UNIV STRASBOURG 1,FAC CHIM,CNRS,CHIM ORGAN BIOL LAB,F-67008 STRASBOURG,FRANCE

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 07期

关键词：

D O I：

10.1016/0040-4039(94)02434-D

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In order to prepare new anti-retroviral nucleoside analogues, the effect of the group at C-5' on the addition of lithium and cerium trimethylsilylacetylide on 3'-ketonucleosidcs (R(1) = H, R(1) = TBDMS) derived from adenosine and uridine was studied. The best results in respect of yield (56 to 81%) and diastereoselectivity (95:5 to >98:2) were obtained with a cerium reagent (RCcCl(2)).

引用

页码：1031 / 1034

页数：4

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