IS P75(NGFR) INVOLVED IN DEVELOPMENTAL NEURAL CELL-DEATH

被引：58

作者：

RABIZADEH, S

BREDESEN, DE

机构：

[1] University of California, Los Angeles, CA

来源：

DEVELOPMENTAL NEUROSCIENCE | 1994年 / 16卷 / 3-4期

关键词：

APOPTOSIS; DEGENERATION; NERVE GROWTH FACTOR RECEPTOR; NEUROTROPHIN;

D O I：

10.1159/000112108

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The tumor necrosis factor receptor superfamily includes twelve members, at feast two of which - tumor necrosis factor receptor I and FAS/Apo-1 - induce cell death following ligand binding. This review summarizes data suggesting that two other members of the family - p75(NGFR) and CD40 - achieve a similar effect in the inverse fashion: they induce apoptosis constitutively when unbound by their respective ligands, with the induction of apoptosis being inhibited by the binding of their respective ligands. The potential roles that such receptors may play in development and pathological processes are discussed.

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页码：207 / 211

页数：5

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