SINGLE DOSE DOXYCYCLINE THERAPY FOR SCRUB TYPHUS

被引：64

作者：

BROWN, GW ^{[1
]}

SAUNDERS, JP ^{[1
]}

SINGH, S ^{[1
]}

HUXSOLL, DL ^{[1
]}

SHIRAI, A ^{[1
]}

机构：

[1] USA,INST MED RES,MED RES UNIT,KUALA LUMPUR,MALAYSIA

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1978年 / 72卷 / 04期

关键词：

D O I：

10.1016/0035-9203(78)90138-4

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A single dose of 200 mg of doxycycline was shown to be as effective as a seven day course of tetracycline, in patients suspected of having scrub typhus. 65 (44%) of the 149 patients studied fulfilled the criteria for definite diagnosis of scrub typhus; 10 had an additional diagnosis. Rickettsia tsutsugamushi was isolated from 49 (75 %) patients. There was no difference between the two treatment groups in time to defervescence, abolition of cough and headache, or in the time taken to recover well-being. There were no relapses in either group. Of the remaining 84 patients, a causal diagnosis was achieved in 52. Irrespective of a diagnosis there was no difference in apparent response to either doxycycline or tetracycline. + Major, R. A.M.C. Present Address: Queen Elizabeth Military Hospital, London SE18. © 1978 Oxford university press.

引用

页码：412 / 416

页数：5

共 22 条

[1] SEROLOGICAL DIAGNOSIS OF HUMAN MELIOIDOSIS WITH INDIRECT HEMAGGLUTINATION AND COMPLEMENT FIXATION TESTS [J].