CHEMOTACTIC RESPONSES OF TUMOR-CELLS TO PRODUCTS OF RESORBING BONE

被引：122

作者：

ORR, W

VARANI, J

GONDEK, MD

WARD, PA

MUNDY, GR

机构：

[1] UNIV CONNECTICUT,SCH MED,DEPT PATHOL,FARMINGTON,CT 06032

[2] UNIV CONNECTICUT,SCH MED,DEPT MED,FARMINGTON,CT 06032

来源：

SCIENCE | 1979年 / 203卷 / 4376期

关键词：

D O I：

10.1126/science.569363

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To explore possible mechanisms for the metastasis of malignant cells to bone, a model of tumor cell migration was developed, using Walker carcinosarcoma or malignant lymphoma cells. It was found that bone contains a factor that is strongly chemotactic for tumor cells. This factor is released by a variety of agents that induce resorption of bone. Copyright © 1979 AAAS.

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页码：176 / 179

页数：4

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