CLAVULANIC ACID AND PENICILLIN TREATMENT OF STAPHYLOCOCCUS-AUREUS RENAL INFECTION IN MICE

被引：8

作者：

HEEREMA, MS

MUSHER, DM

WILLIAMS, TW

机构：

[1] METHODIST HOSP,HOUSTON,TX 77030

[2] BAYLOR UNIV,COLL MED,DEPT MICROBIOL & IMMUNOL,HOUSTON,TX 77030

[3] BAYLOR UNIV,COLL MED,DEPT MED,HOUSTON,TX 77030

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1979年 / 16卷 / 06期

关键词：

D O I：

10.1128/AAC.16.6.798

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Clavulanic acid, an inhibitor of beta-lactamase, was used together with penicillin to treat infection caused by a penicillinase-producing Staphylococcus aureus. Clavulanic acid + penicillin administsred to mice, prophylactically or in treatment of established infection, reduced morbidity, bacterial counts in the kidneys, and/or mortality; these differences were statistically significant when compared with those obtained by using penicillin or clavulanic acid alone.

引用

页码：798 / 800

页数：3

共 13 条

[1] EFFECT OF CLAVULANIC ACID ON THE MINIMUM INHIBITORY CONCENTRATION OF BENZYLPENICILLIN, AMPICILLIN, CARBENICILLIN, OR CEPHALOTHIN AGAINST CLINICAL ISOLATES RESISTANT TO BETA-LACTAM ANTIBIOTICS [J].