SYNTHESIS OF BIOLOGICALLY-ACTIVE METABOLITES OF 7-METHYLBENZ[A]ANTHRACENE

被引：30

作者：

LEE, HM ^{[1
]}

HARVEY, RG ^{[1
]}

机构：

[1] UNIV CHICAGO,BEN MAY LAB CANC RES,CHICAGO,IL 60637

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1979年 / 44卷 / 26期

关键词：

D O I：

10.1021/jo00394a043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Syntheses are described of the trans 3, 4-dihydro diol (la) and the corresponding anti diol epoxide (2) of 7-methylben.z[o]anthracene, implicated as proximate and ultimate carcinogenic metabolites, respectively, of this potent precarcinogen. Additional syntheses are reported of the related trans 1, 2-dihydro diol (3a), the corresponding anti and syn diol epoxides, and 2- and 3-hydroxy-7-methylbenz[a]anthracene, additional potential metabolites of this polycyclic hydrocarbon. © 1979, American Chemical Society. All rights reserved.

引用

页码：4948 / 4953

页数：6

共 36 条

[1]

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[2]

BELL HM, 1966, J AM CHEM SOC, V88, P1463

[3] THE REDUCTION OF ORTHO-QUINONES WITH LITHIUM ALUMINIUM HYDRIDE [J].