A METHOD FOR THE CHROMATOGRAPHIC RESOLUTION OF TETRAHYDROPYRAN-2-ONES

被引：10

作者：

ASHWORTH, P

BELAGALI, SL

CASSON, S

MARCZAK, A

KOCIENSKI, P

机构：

[1] Chemistry Department, The University, Southampton

来源：

TETRAHEDRON | 1991年 / 47卷 / 47期

关键词：

CHROMATOGRAPHIC RESOLUTION; TETRAHYDROPYRAN-2-ONES; LACTONES; ORTHOLACTONES; 1,5,7-TRIOXASPIRO[5.5]UNDECANE;

D O I：

10.1016/S0040-4020(01)80729-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The spirocyclic ortholactones prepared from certain tetrahydropyran-2-ones (valerolactones) and (1R)-1-phenylpropan-1,3-diol are readily separable by flash chromatography on silica gel. Hydrolysis of the resolved ortholactones then provides the pure homochiral lactones.

引用

页码：9939 / 9946

页数：8

共 19 条

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